Diffusion‐weighted magnetic resonance imaging differentiates Parkinsonian variant of multiple‐system atrophy from progressive supranuclear palsy
Identifieur interne : 001927 ( Main/Corpus ); précédent : 001926; suivant : 001928Diffusion‐weighted magnetic resonance imaging differentiates Parkinsonian variant of multiple‐system atrophy from progressive supranuclear palsy
Auteurs : Dominic C. Paviour ; John S. Thornton ; Andrew J. Lees ; H. Rolf J GerSource :
- Movement Disorders [ 0885-3185 ] ; 2007-01.
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Abstract
Progressive supranuclear palsy (PSP) and the parkinsonian variant of multiple‐system atrophy (MSA‐P) may present with a similar phenotype. Magnetic resonance diffusion‐weighted imaging (DWI) has been shown to be a sensitive discriminator of MSA‐P from Parkinson's disease (PD). We studied 20 PSP, 11 MSA‐P, 12 PD patients and 7 healthy controls in order to investigate whether regional apparent diffusion coefficients (rADCs) help distinguish PSP and MSA‐P; whether rADCs are correlated with clinical disease severity scores; and the relationship between brainstem and cerebellar volumes and rADCs in PSP and MSA‐P. The Unified Parkinson's Disease Rating Scale, Hoehn and Yahr score, Mini Mental State Examination, and frontal assessment battery were recorded in all patients. Regional ADCs were measured in the middle cerebellar peduncle (MCP), caudal and rostral pons, midbrain, decussating fibers of the superior cerebellar peduncle, thalamus, putamen, globus pallidus, caudate nucleus, corpus callosum, frontal and parietal white matter, as well as the centrum semiovale. In MSA‐P, rADCs in the MCP and rostral pons were significantly greater than in PSP (P < 0.001 and 0.009) and PD (P < 0.001 and = 0.002). Stepwise logistic regression revealed that the MCP rADC distinguishes MSA‐P from PSP with a sensitivity of 91% and a specificity of 84%. Increased brainstem rADCs were associated with motor deficit in MSA‐P and PSP. Increased rADCs in the pons and MCP were associated with smaller pontine and cerebellar volumes in MSA‐P. rADCs distinguish MSA‐P from PSP. These have a clinical correlate and are associated with reduced brainstem and cerebellar volumes. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.21204
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Thornton</name><affiliation><mods:affiliation>Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew J. 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Rolf J Ger</name><affiliation><mods:affiliation>Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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Magnetic resonance diffusion‐weighted imaging (DWI) has been shown to be a sensitive discriminator of MSA‐P from Parkinson's disease (PD). We studied 20 PSP, 11 MSA‐P, 12 PD patients and 7 healthy controls in order to investigate whether regional apparent diffusion coefficients (rADCs) help distinguish PSP and MSA‐P; whether rADCs are correlated with clinical disease severity scores; and the relationship between brainstem and cerebellar volumes and rADCs in PSP and MSA‐P. The Unified Parkinson's Disease Rating Scale, Hoehn and Yahr score, Mini Mental State Examination, and frontal assessment battery were recorded in all patients. Regional ADCs were measured in the middle cerebellar peduncle (MCP), caudal and rostral pons, midbrain, decussating fibers of the superior cerebellar peduncle, thalamus, putamen, globus pallidus, caudate nucleus, corpus callosum, frontal and parietal white matter, as well as the centrum semiovale. In MSA‐P, rADCs in the MCP and rostral pons were significantly greater than in PSP (P < 0.001 and 0.009) and PD (P < 0.001 and = 0.002). Stepwise logistic regression revealed that the MCP rADC distinguishes MSA‐P from PSP with a sensitivity of 91% and a specificity of 84%. Increased brainstem rADCs were associated with motor deficit in MSA‐P and PSP. Increased rADCs in the pons and MCP were associated with smaller pontine and cerebellar volumes in MSA‐P. rADCs distinguish MSA‐P from PSP. These have a clinical correlate and are associated with reduced brainstem and cerebellar volumes. © 2006 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Dominic C. Paviour PhD, MRCP</name><affiliations><json:string>Sara Koe PSP Research Centre, Institute of Neurology, University College London, London, United Kingdom</json:string><json:string>Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom</json:string></affiliations></json:item><json:item><name>John S. Thornton PhD</name><affiliations><json:string>Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, United Kingdom</json:string><json:string>Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Andrew J. 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Magnetic resonance diffusion‐weighted imaging (DWI) has been shown to be a sensitive discriminator of MSA‐P from Parkinson's disease (PD). We studied 20 PSP, 11 MSA‐P, 12 PD patients and 7 healthy controls in order to investigate whether regional apparent diffusion coefficients (rADCs) help distinguish PSP and MSA‐P; whether rADCs are correlated with clinical disease severity scores; and the relationship between brainstem and cerebellar volumes and rADCs in PSP and MSA‐P. The Unified Parkinson's Disease Rating Scale, Hoehn and Yahr score, Mini Mental State Examination, and frontal assessment battery were recorded in all patients. Regional ADCs were measured in the middle cerebellar peduncle (MCP), caudal and rostral pons, midbrain, decussating fibers of the superior cerebellar peduncle, thalamus, putamen, globus pallidus, caudate nucleus, corpus callosum, frontal and parietal white matter, as well as the centrum semiovale. In MSA‐P, rADCs in the MCP and rostral pons were significantly greater than in PSP (P > 0.001 and 0.009) and PD (P > 0.001 and = 0.002). Stepwise logistic regression revealed that the MCP rADC distinguishes MSA‐P from PSP with a sensitivity of 91% and a specificity of 84%. Increased brainstem rADCs were associated with motor deficit in MSA‐P and PSP. Increased rADCs in the pons and MCP were associated with smaller pontine and cerebellar volumes in MSA‐P. rADCs distinguish MSA‐P from PSP. 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Magnetic resonance diffusion‐weighted imaging (DWI) has been shown to be a sensitive discriminator of MSA‐P from Parkinson's disease (PD). We studied 20 PSP, 11 MSA‐P, 12 PD patients and 7 healthy controls in order to investigate whether regional apparent diffusion coefficients (rADCs) help distinguish PSP and MSA‐P; whether rADCs are correlated with clinical disease severity scores; and the relationship between brainstem and cerebellar volumes and rADCs in PSP and MSA‐P. The Unified Parkinson's Disease Rating Scale, Hoehn and Yahr score, Mini Mental State Examination, and frontal assessment battery were recorded in all patients. Regional ADCs were measured in the middle cerebellar peduncle (MCP), caudal and rostral pons, midbrain, decussating fibers of the superior cerebellar peduncle, thalamus, putamen, globus pallidus, caudate nucleus, corpus callosum, frontal and parietal white matter, as well as the centrum semiovale. In MSA‐P, rADCs in the MCP and rostral pons were significantly greater than in PSP (P < 0.001 and 0.009) and PD (P < 0.001 and = 0.002). Stepwise logistic regression revealed that the MCP rADC distinguishes MSA‐P from PSP with a sensitivity of 91% and a specificity of 84%. Increased brainstem rADCs were associated with motor deficit in MSA‐P and PSP. Increased rADCs in the pons and MCP were associated with smaller pontine and cerebellar volumes in MSA‐P. rADCs distinguish MSA‐P from PSP. 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Magnetic resonance diffusion‐weighted imaging (DWI) has been shown to be a sensitive discriminator of MSA‐P from Parkinson's disease (PD). We studied 20 PSP, 11 MSA‐P, 12 PD patients and 7 healthy controls in order to investigate whether regional apparent diffusion coefficients (rADCs) help distinguish PSP and MSA‐P; whether rADCs are correlated with clinical disease severity scores; and the relationship between brainstem and cerebellar volumes and rADCs in PSP and MSA‐P. The Unified Parkinson's Disease Rating Scale, Hoehn and Yahr score, Mini Mental State Examination, and frontal assessment battery were recorded in all patients. Regional ADCs were measured in the middle cerebellar peduncle (MCP), caudal and rostral pons, midbrain, decussating fibers of the superior cerebellar peduncle, thalamus, putamen, globus pallidus, caudate nucleus, corpus callosum, frontal and parietal white matter, as well as the centrum semiovale. In MSA‐P, rADCs in the MCP and rostral pons were significantly greater than in PSP (<i>P</i> < 0.001 and 0.009) and PD (<i>P</i> < 0.001 and = 0.002). Stepwise logistic regression revealed that the MCP rADC distinguishes MSA‐P from PSP with a sensitivity of 91% and a specificity of 84%. Increased brainstem rADCs were associated with motor deficit in MSA‐P and PSP. Increased rADCs in the pons and MCP were associated with smaller pontine and cerebellar volumes in MSA‐P. rADCs distinguish MSA‐P from PSP. These have a clinical correlate and are associated with reduced brainstem and cerebellar volumes. © 2006 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Diffusion‐weighted magnetic resonance imaging differentiates Parkinsonian variant of multiple‐system atrophy from progressive supranuclear palsy</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Diffusion‐Weighted MRI</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Diffusion‐weighted magnetic resonance imaging differentiates Parkinsonian variant of multiple‐system atrophy from progressive supranuclear palsy</title></titleInfo><name type="personal"><namePart type="given">Dominic C.</namePart><namePart type="family">Paviour</namePart><namePart type="termsOfAddress">PhD, MRCP</namePart><affiliation>Sara Koe PSP Research Centre, Institute of Neurology, University College London, London, United Kingdom</affiliation><affiliation>Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom</affiliation><description>Correspondence: Sara Koe PSP Research Centre, Institute of Neurology, 1 Wakefield Street, London WC1N, United Kingdom</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John S.</namePart><namePart type="family">Thornton</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, United Kingdom</affiliation><affiliation>Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andrew J.</namePart><namePart type="family">Lees</namePart><namePart type="termsOfAddress">MD, FRCP</namePart><affiliation>Sara Koe PSP Research Centre, Institute of Neurology, University College London, London, United Kingdom</affiliation><affiliation>Reta Lila Weston Institute of Neurological Studies, University College London, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. Rolf</namePart><namePart type="family">Jäger</namePart><namePart type="termsOfAddress">MD, FRCP</namePart><affiliation>Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, United Kingdom</affiliation><affiliation>Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-01</dateIssued><dateCaptured encoding="w3cdtf">2006-03-31</dateCaptured><dateValid encoding="w3cdtf">2006-07-23</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">3</extent><extent unit="references">29</extent><extent unit="words">4828</extent></physicalDescription><abstract lang="en">Progressive supranuclear palsy (PSP) and the parkinsonian variant of multiple‐system atrophy (MSA‐P) may present with a similar phenotype. Magnetic resonance diffusion‐weighted imaging (DWI) has been shown to be a sensitive discriminator of MSA‐P from Parkinson's disease (PD). We studied 20 PSP, 11 MSA‐P, 12 PD patients and 7 healthy controls in order to investigate whether regional apparent diffusion coefficients (rADCs) help distinguish PSP and MSA‐P; whether rADCs are correlated with clinical disease severity scores; and the relationship between brainstem and cerebellar volumes and rADCs in PSP and MSA‐P. The Unified Parkinson's Disease Rating Scale, Hoehn and Yahr score, Mini Mental State Examination, and frontal assessment battery were recorded in all patients. Regional ADCs were measured in the middle cerebellar peduncle (MCP), caudal and rostral pons, midbrain, decussating fibers of the superior cerebellar peduncle, thalamus, putamen, globus pallidus, caudate nucleus, corpus callosum, frontal and parietal white matter, as well as the centrum semiovale. In MSA‐P, rADCs in the MCP and rostral pons were significantly greater than in PSP (P < 0.001 and 0.009) and PD (P < 0.001 and = 0.002). Stepwise logistic regression revealed that the MCP rADC distinguishes MSA‐P from PSP with a sensitivity of 91% and a specificity of 84%. Increased brainstem rADCs were associated with motor deficit in MSA‐P and PSP. Increased rADCs in the pons and MCP were associated with smaller pontine and cerebellar volumes in MSA‐P. rADCs distinguish MSA‐P from PSP. These have a clinical correlate and are associated with reduced brainstem and cerebellar volumes. © 2006 Movement Disorder Society</abstract><note type="funding">PSP (Europe) Association</note><subject lang="en"><genre>Keywords</genre><topic>diffusion‐weighted MRI</topic><topic>PSP</topic><topic>MSA</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>68</start><end>74</end><total>7</total></extent></part></relatedItem><identifier type="istex">39C22D4ABECE9D815AE008CBE923A2991AADD549</identifier><identifier type="DOI">10.1002/mds.21204</identifier><identifier type="ArticleID">MDS21204</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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